|
T17030 |
Tegoprazan
|
|
ATPase
,
Proton pump
|
|
Tegoprazan is a potassium-competitive acid blocker and is a potent, oral active, and highly selective inhibitor of gastric H+/K+-ATPase. That could control gastric acid secretion and motility (IC50: ranging from 0.29-0.5... |
|
T38612 |
Linaprazan glurate
|
|
Others
|
|
Linaprazan glurate inhibits exogenously or endogenously stimulated gastric acid secretion. Linaprazan glurate can be used in studies about gastrointestinal inflammatory diseases and peptic ulcer diseases. |
|
T4579 |
Pentagastrin
|
ICI-50123 |
Others
,
cholecystokinin
|
|
Pentagastrin (ICI-50123) is a synthetic polypeptide that has effects like gastrin when given parenterally, which can cause the secretion and synthesis of salivary proteins. |
|
T4981 |
Anisotropine Methylbromide
|
|
Prostaglandin Receptor
,
AChR
|
|
Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion. |
|
T22724 |
Dimaprit dihydrochloride
|
|
NOS
,
NO Synthase
,
Histamine Receptor
|
|
Dimaprit dihydrochloride is a selective histamine H2 receptor agonist. Dimaprit dihydrochloride also inhibits nNOS with an IC50 of 49 μM. It can stimulate gastric acid secretion. |
|
T0498 |
Salsalate
|
Disalicylic acid,Salicylsalicylic acid,Sasapyrine,NSC-49171 |
Reactive Oxygen Species
,
COX
|
|
Salsalate (Sasapyrine) is an orally available salicylate and non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic and antipyretic activities. |
|
T0686 |
Orlistat
|
Ro-18-0647,Tetrahydrolipstatin |
Apoptosis
,
Others
,
Fatty Acid Synthase
|
|
Orlistat (Tetrahydrolipstatin) is an Intestinal Lipase Inhibitor. The mechanism of action of orlistat is as a Lipase Inhibitor. |
|
T6700 |
Tenatoprazole
|
TU-199 |
Proton pump
|
|
Tenatoprazole (TU-199), a prodrug of the proton pump inhibitor (PPI) class, can inhibit proton transport (IC50: 3.2 μM). |
|
T8599 |
Betazole dihydrochloride
|
Betazole hydrochloride |
Histamine Receptor
|
|
Betazole dihydrochloride (Betazole hydrochloride) is an agonist of H2 receptor. |
|
T1756L |
Ilaprazole
|
IY81149,IY 81149,IY-81149 |
Proton pump
,
TOPK
|
|
Ilaprazole (IY-81149) is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Studies also showed that Ilaprazole significantly prevented the developm... |
|
T1756 |
Ilaprazole sodium
|
IY-81149 sodium |
Proton pump
,
TOPK
|
|
Ilaprazole sodium (IY-81149 sodium) , a substituted benzimidazole prodrug, is a selective and irreversible proton pump inhibitor. A weak base, Ilaprazole accumulates in the acidic environment of the secretory canaliculus... |
|
T0674 |
Lansoprazole
|
A-65006,AG-1749 |
Proton pump
,
Phospholipase
,
Antibacterial
|
|
Lansoprazole (A-65006) is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is fo... |
|
T8388 |
Vonoprazan
|
TAK-438 (free base) |
Proton pump
|
|
Vonoprazan (TAK-438 (free base)) is an orally active potassium-competitive acid blocker.Vonoprazan can be used for the treatment of gastroduodenal ulcer and reflux esophagitis |
|
T21254 |
Vonoprazan Fumarate
|
TAK-438,TAK 438,Vonoprazan Fumurate,TAK438 |
Proton pump
|
|
Vonoprazan Fumarate (TAK438) , a novel potassium-competitive acid blocker, inhibits gastric acid secretion. Vonoprazan Fumarate (TAK438) inhibited H+,K+-ATPase activity in porcine gastric microsomes with IC50 value of 19... |
|
T7615 |
Xenopsin
|
Xenopsin(2TFA) |
Others
|
|
Xenopsin (Xenopsin(2TFA))(2TFA) is a neurotensin-like octapeptide previously isolated from amphibian skin. |
|
T1627 |
Famotidine
|
MK-208 |
Histamine Receptor
|
|
Famotidine (MK-208) is a propanimidamide and histamine H2-receptor antagonist with antacid activity. As a competitive inhibitor of histamine H2-receptors located on the basolateral membrane of the parietal cell, famotidi... |
|
T15005 |
CP-66948
|
|
Histamine Receptor
|
|
CP-66948 is a potent histamine H2 receptor antagonist with inhibitory effect on gastric acid secretion and can be used to protect gastric and intestinal mucosa. |
|
T13145 |
Thiazolidinone-Derivatives-1
|
|
Others
|
|
|
|
TP1309 |
Gastric mucin
|
|
Antibacterial
,
Antibiotic
|
|
Gastric mucin is a large glycoprotein which is thought to play a major role in the protection of the gastrointestinal tract from acid, proteases, pathogenic microorganisms, and mechanical trauma. |
|
T10221 |
Abeprazan hydrochloride
|
DWP14012 hydrochloride,Fexuprazan hydrochloride |
Proton pump
|
|
Abeprazan hydrochloride (Fexuprazan hydrochloride) is an effective reversible potassium-competitive acid blocker with oral activity, inhibiting H+, K+ -atPase by competitive binding to potassium ions without acid activat... |
|
T20561L |
BPC 157 acetate(137525-51-0 free base)
|
BPC157 acetate,BPC-157 acetate,Bpc 15 acetate,Bpc15 acetate,Bpc-15 acetate |
Others
|
|
BPC 157 acetate(137525-51-0 free base) is a 15-amino acid fragment of a gastric peptide (BPC) which has hepatoprotective effects. |
|
T0081 |
Lafutidine
|
FRG-8813 |
5-HT Receptor
,
Histamine Receptor
|
|
Lafutidine (FRG-8813) is a newly developed histamine H(2)-receptor antagonist, which can inhibit gastric acid secretion. |
|
TP2030L1 |
Gastrin I (human) acetate
|
Gastrin I (human) acetate(10047-33-3 free base),Gastrin-17 acetate,Little gastrin I acetate |
cholecystokinin
|
|
Gastrin I (human) acetate (Gastrin-17 acetate) is the endogenous peptide produced in the stomach, and increases gastric acid secretion via cholecystokinin 2 (CCK2) receptor. |
|
T0157 |
Roxatidine Acetate hydrochloride
|
HOE 760,Roxatidine Acetate HCl |
Histamine Receptor
|
|
Roxatidine Acetate hydrochloride (HOE 760) is a specific and competitive histamin H2-receptor antagonist. It inhibits gastric acid secretion and ulcer formation. |
|
TP1705 |
Gastrin I (1-14), human
|
|
Others
|
|
Gastrin I (1-14), human, represents the 1-14 peptide fragment of human gastrin I, an endogenous gastrointestinal peptide hormone. This compound is the principal hormonal regulator of gastric acid secretion. |
|
T37588L |
GIP (1-30) amide, porcine acetate
|
|
IGF-1R
|
|
GIP (1-30) amide, porcine acetate is an agonist of fully glucose-dependent insulinotropic polypeptide (GIP) receptor. GIP (1-30) amide, porcine acetate can weakly inhibit gastric acid secretion and strongly stimulate ins... |
|
T68016 |
Spiroglumide
|
CR-2194 |
cholecystokinin
|
|
Spiroglumide, a CCKB-gastrin antagonist that inhibits dose-dependent pentagastrin-induced acid hypersecretion with an ID50 of 20.1 (8.67-46.4) mg / kg, could be used to explore the physiological role of gastrin in the re... |
|
TP2018L |
GIP (human) acetate
|
GIP (human) acetate(100040-31-1 Free base) |
IGF-1R
|
|
GIP (human) acetate is a stimulator of glucose-dependent insulin secretion and a weak inhibitor of gastric acid secretion. GIP (human) acetate plays a vital role in lipid metabolism and the development of obesity. |
|
T1467 |
Acemetacin
|
K-708,TVX 1322 |
COX
|
|
Acemetacin (TVX 1322) is a carboxymethyl ester of indometacin. It is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is thought to be mainly through its active metaboli... |
|
T0797 |
Cimetidine
|
SKF-92334 |
Histamine Receptor
|
|
Cimetidine (SKF-92334) is a histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEP... |
|
T6929 |
Pantoprazole sodium
|
Pantecta,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),BY-1023 sodium,Pantoloc |
Apoptosis
,
Others
,
Proton pump
,
HIF
,
Autophagy
|
|
Pantoprazole sodium (Pantecta) is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole sodium is a lipophilic, weak base that crosses the parietal cell membrane and enters... |
|
T22391 |
Omeprazole Sodium
|
|
P450
,
Proton pump
,
Antibacterial
,
Autophagy
|
|
Omeprazole Sodium is a proton pump inhibitor(PPI) and suppresses gastric acid secretion. Omeprazole Sodium is a potent neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor). Omeprazole Sodium shows competitive... |
|
T2686 |
Esomeprazole Magnesium
|
(S)-Omeprazole magnesium,NEXIUM,(-)-Omeprazole magnesium |
ATPase
,
Proton pump
|
|
Esomeprazole Magnesium (NEXIUM) is the S-isomer of omeprazole, can reduce gastric acid secretion with selective and irreversible proton pump inhibitor activity.Esomeprazole magnesium acts as an exosome inhibitor by block... |
|
T16865 |
SCH28080
|
|
ATPase
,
Proton pump
|
|
SCH28080 is a reversible and K+-competitive inhibitor of gastric H+/K+-ATPase with an IC50 value of 20 nM (rabbit microsomal membrane).SCH28080 is a potent inhibitor of acid secretion in vivo with anti-ulcer activity, an... |
|
T21385 |
Cinitapride
|
Paxapride,Cidine,cinitapride tartrate,Blaston,Cintapro,Cinmove |
5-HT Receptor
|
|
Cinitapride (Blaston) is a gastroprokinetic agent. It slows the actions of the muscles to reduce the symptoms of conditions such as acid reflux, delayed gastric emptying, and ulcer dyspepsia. Cinitapride acts as an antag... |
|
TP1325L |
Gastrin-Releasing Peptide, human(TFA)
|
|
Others
|
|
Gastrin-Releasing Peptide, human(TFA) is a regulatory human peptide that elicits gastrin release and regulates gastric acid secretion and enteric motor function. The post-ganglionic fibers of the vagus nerve that innerva... |
|
T77599 |
Methyl retinoate
|
Retinoic acid, methyl ester |
Others
|
|
Methyl retinoate (Retinoic acid, methyl ester) induces aseptic inflammation at the site of administration in in vivo experiments, which causes an increase in the number of leukocytes in the blood and a decrease in the le... |
|
T1083L |
Theophylline monohydrate
|
Quibron |
HDAC
,
PDE
,
Adenosine Receptor
|
|
Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline monohydrate is a ... |
|
T31958 |
Glycine-pentagastrin
|
Glycine pentagastrin,Boc-gly-trp-met-asp-phe-NH2,Tbgtmap |
|
|
Glycine-pentagastrin can enhance gastric mucosal defence mechanisms against acid and protect the gastric mucosa from experimental injury. |
|
T27669 |
JNJ-26070109
|
JNJ26070109 |
|
|
JNJ-26070109, an antagonist of cholecystokinin CCK2 receptor, inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rat. |
|
T69805 |
AU-006
|
|
|
|
AU-006 is an anti-ulcer drug which is effective in the treatment of gastric ulcers by inhibiting gastric acid secretion. |
|
T27092 |
CS-526
|
R-105266,R 105266,R105266 |
|
|
CS-526 is a proton pump inhibitor. The inhibitory mechanism of CS-526 on H+,K+-ATPase was a competitive antagonism to the K+ binding site of H+,K+-ATPase, and it was also a reversible inhibition. CS-526 has a potent anti... |
|
T20660 |
Revaprazan
|
SB-641257,SB 641257,SB641257 |
|
|
Revaprazan is a novel, selective potassium-competitive acid blocker, to be specific, it reversibly inhibits gastric H(+)/K(+)-ATPase and shows effective acid suppression comparable to PPIs. |
|
T26090 |
Rioprostil
|
TR 4698,TR4698,Rioprostilum,TR-4698 |
|
|
Rioprostil is a methyl prostaglandin E1 analog that decreases gastric acid secretion and enhances the gastric mucus-bicarbonate barrier. It is effective in the treatment of gastric ulcers and gives significant protection... |
|
T39583 |
Zastaprazan
|
|
|
|
Zastaprazan, a proton pump inhibitor (WO2018008929), is utilized in the research of gastrointestinal inflammatory diseases and conditions related to gastric acid. |
|
T15722 |
Lavoltidine
|
Loxtidine,AH-234844 |
Histamine Receptor
|
|
Lavoltidine is an orally active and irreversible histamine H2-receptor antagonist. Lavoltidine strongly suppresses gastric acid secretion and also induces hypergastrinemia. |
|
T30250 |
AZD0865
|
AZD-0865,AZD 0865 |
|
|
AZD0865 is an effective drug that inhibits gastric H(+), K(+) -ATPase activity and acid formation in vitro, with rapid onset. |
|
T69164 |
Dibenamine
|
|
|
|
Dibenamine is an alpha adrenergic antagonist that blocks basal and histamine-stimulated gastric acid secretion. |
|
T32224 |
Isopropamide
|
Priazimide,Dipramide,Piaccamide,Chloroisopropamide,Dipramid |
|
|
Isopropamide (R5) is a long-acting anticholinergic drug. It is used to treat peptic ulcers and other gastrointestinal disorders involving excess gastric acid (gastrointestinal acidosis) and hyperactivity. |
|
T13261 |
CCK-B Receptor Antagonist 1
|
|
Others
|
|
CCK-B Receptor Antagonist 1 is a cholecystokinin B (CCK-B) receptor agonist and has the potential of reducing the secretion of gastric acid. |
